401 Biochemistry-Molecular Biology I (4) First semester of a two-course sequence providing in-depth coverage of biochemistry and molecular biology. Covers amino acid structure and chemistry, protein structure and chemistry, protein folding, enzyme behavior and function, reaction mechanisms, catabolism and energy transfer, synthetic metabolism including photosynthesis, and protein transport.
(DE) Prerequisite(s): Biology 240 and Chemistry 350, 360, and 369.
402 Biochemistry-Molecular Biology II (4) Second semester of a two-course sequence providing in-depth coverage of biochemistry and molecular biology. Covers structure of DNA and RNA, experimental methods of analyzing nucleic acids, mechanisms of RNA and protein synthesis, mechanisms of DNA replication, repair and recombination, chromosome structure and function, regulation of gene expression, genome structure and genomics, and mechanisms of biological regulation.
(DE) Prerequisite(s): Biology 240 and Chemistry 350, 360, and 369.
403 Advanced Genetics Laboratory (3) Experiments illustrating methods in modern genetics: techniques in classical, cyto-molecular, and developmental genetics. Using model organisms, especially Drosophila and mouse.
Contact Hour Distribution: Laboratory and lecture.
(DE) Prerequisite(s): Biology 240 and Chemistry 360.
404 Plant Molecular Biology (3) Introduction to current research approaches and methodologies in plant developmental biology and molecular genetics.
Contact Hour Distribution: Laboratory and lecture.
(DE) Prerequisite(s): Biology 240.
419 Cellular and Comparative Biochemistry Lab (2) Experiments with enzymes, nucleic acids, and membranes and organelles. Chromatography, kinetics, hybridization, sequencing, and immunochemical methods.
(DE) Prerequisite or (DE) Corequisite: 401 or 410.
421 Cell and Tissue Structure and Function (4) Study of animal cells and tissues at light and electron microscope levels.
Contact Hour Distribution: 2 hours and 2 labs.
(DE) Prerequisite(s): Biology 140.
440 General Physiology (3) Principles of cellular and organ-system animal physiology.
(DE) Prerequisite(s): Biology 140.
(DE) Corequisite(s): Chemistry 350 and 360.
Recommended Background: Physics 221 and 222.
465 Human Genetics (3) Genetic and molecular principles and problems of human inheritance.
(DE) Prerequisite(s): Biology 240.
471 Biophysical Chemistry (3) Physicochemical principles with applications to biological systems. Thermodynamics; chemical equilibrium; solution chemistry; transport; electrochemistry; kinetics; enzyme catalyzed reactions. (Same as Chemistry 471.)
(DE) Prerequisite(s): Chemistry 350 and 360, Mathematics 125, and general biology or consent of instructor.
480 Physiology of Exercise (3) (See Exercise Science 480.)
481 Biophysical Chemistry (3) Physicochemical principles with applications to biological systems. Elementary quantum chemistry; interactions of light with biological molecules; optical and magnetic spectroscopy; light scattering; case studies of selected macromolecules. (Same as Chemistry 481.)
(DE) Prerequisite(s): Chemistry 350 and 360, Mathematics 125, and general biology or consent of instructor.
500 Thesis (1-15)
Grading Restriction: P/NP only.
Repeatability: May be repeated.
502 Registration for Use of Facilities (1-15) Required for the student not otherwise registered during any semester when student uses university facilities and/or faculty time before degree is completed.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated.
Credit Restriction: May not be used toward degree requirements.
510 Computational Structural Biochemistry (1) Introduction to computational tools, internet resources and databases for biological research to analyze and model protein structures and to study protein-ligand interactions.
(DE) Corequisite(s): 511.
Registration Permission: Consent of instructor.
511 Advanced Protein Chemistry and Cellular Biology (3) Cellular structure and function at molecular and supramolecular level in progression: protein structure and function; membrane structure and function; bioenergetics and membrane proteins.
(DE) Corequisite(s): 510.
Recommended Background: Prior knowledge of cell biology and biochemistry.
Registration Permission: Consent of instructor.
512 Advanced Molecular Biology (3) Regulation of nucleic acid expression and protein activity. Nucleic acid structure and function; replication and repair of nucleic acids; gene expression; protein synthesis; post-translational protein modification; mitosis and meiosis; cell cycle and cell growth.
(DE) Prerequisite(s): 511 or consent of instructor.
513 Advanced Protein Biochemistry and Cell Biology II (3) Advanced topics of cellular function and regulation of cell division and growth, and structure and function of supramolecular structures: cytoskeleton and cell junctions and adhesions.
(DE) Prerequisite(s): 511.
515 Experimental Techniques I (2-4) Introduction to modern experimental methodology and instrumentation in biochemistry, molecular biology and cell biology, including cell culture; spectrophotometry; microscopy; nucleic acid purification and analysis; protein assays; enzyme purification; electrophysiology; computer analysis of nucleic acid and protein sequences. Team-taught lecture/demonstration format.
Repeatability: May be repeated. Maximum 6 hours.
Comment(s): Primarily for departmental graduate students.
516 Experimental Techniques II (2-4) Laboratory rotations. Students work in laboratory of faculty member on clearly defined project. Written proposal and oral report required.
Repeatability: May be repeated. Maximum 8 hours.
(DE) Prerequisite(s): 515.
Comment(s): Primarily for departmental graduate students.
517 Physical Biochemistry (3) Physics and chemistry of biological systems and molecules. Thermodynamics; diffusion and transport; physical chemistry of macromolecules; enzyme kinetics; binding reactions; spectroscopy; electrophysiology.
(DE) Prerequisite(s): 511 or consent of instructor.
520 Special Topics (1-3) Selected directed readings or special course in topics of current interest. Consult departmental listings for offerings.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated with consent of instructor. Maximum 6 hours.
522 Advanced Plant Physiology I (3) Plant biochemistry and metabolism: respiration, photosynthesis, carbon partitioning, and biosynthesis of specialized plant products: terpenoids, alkaloids, phenolics and plant growth regulators.
(DE) Prerequisite(s): 401 and one semester of introductory plant physiology or cell biology.
523 Advanced Plant Physiology II (3) Growth and differentiation of plants at molecular, cellular and organismal levels. Regulation of development; macromolecular interpretation of differentiation, dormancy, germination, flowering, and senescence.
(DE) Prerequisite(s): 401 and one semester of introductory plant physiology or cell biology.
525 Graduate Research Participation (3-12) Tutorial laboratory experience.
Repeatability: May be repeated. Maximum 12 hours.
530 Experimental Design and Analysis (3) Development of skills in strategies of experimental design and interpretation of experimental results. Critical discussion of research articles illustrating issues in experimental design. Preparation of grant proposal in standard format to be read and discussed by class and by panel of faculty expert in area of proposal.
Registration Permission: Consent of instructor.
550 Advanced Concepts in Neurobiology/Physiology (3) Concepts related to neurobiology/ physiology with information taken from current literature. Predominantly lecture format with student participation. Specific subject area to be announced.
Registration Permission: Consent of instructor.
552 Physiology of Hormones (3) Cellular and organismal action of hormones in invertebrate and vertebrate animals. (Same as Animal Science 556.)
Recommended Background: 402, 440 or equivalent courses.
Registration Permission: Consent of instructor.
559 Biophysical Crystallography (3) Theories and practices of X-ray diffraction, neutron diffraction and neutron scattering to elucidate the structure of nucleic acids, proteins, nucleosomes, ribosomes and viruses. Application of 3-D structures in designing drugs against AIDS, cancer, cardiac disease and neurodegenerative disorders.
Recommended Background: 401 or two 300-level chemistry courses or Physics 240.
Registration Permission: Consent of instructor.
560 Advanced Concepts in Structural Biology/Biochemistry (3) Concepts related to structural biology/biochemistry with information taken from current literature. Predominantly lecture format with student participation. Specific subject area to be announced.
Repeatability: May be repeated. Maximum 12 hours.
Registration Permission: Consent of instructor.
562 Introduction to Electron Microscopy – Transmission Electron Microscope (4) Practical application to techniques for preparation of biological samples for viewing in transmission electron microscopy. Use of microscope and ancillary equipment, darkroom techniques, preparation of materials for publication and special project.
Contact Hour Distribution: Two 3-hour labs.
Comment(s): Approved graduate students in department only.
564 Introduction to Electron Microscopy-Scanning Electron Microscope (3) Practical introduction to techniques of electron microscopy and to scanning electron microscope. Use of microscope, introduction to darkroom techniques and digital image processing, preparation of samples for observation, and special project.
Contact Hour Distribution: 2 hours and 1 lab.
Registration Permission: Consent of instructor.
580 Advanced Concepts in Genetics/Developmental Biology (3) Concepts related to genetics/ developmental biology with information taken from current literature. Predominately lecture format with student participation. Specific subject area to be announced.
Repeatability: May be repeated. Maximum 12 hours.
Registration Permission: Consent of instructor.
591 Foreign Study (1-15)
Repeatability: May be repeated. Maximum 15 hours.
592 Off-Campus Study (1-15)
Repeatability: May be repeated. Maximum 15 hours.
593 Independent Study (1-15)
Repeatability: May be repeated. Maximum 15 hours.
600 Doctoral Research and Dissertation (3-15)
Grading Restriction: P/NP only.
Repeatability: May be repeated.
601 Departmental Seminar (1) Invited speakers. Topics posted in advance. Required every semester in residence.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 15 hours.
603 Graduate Research Colloquium (1) Seminars and lectures dealing with current advances in fields of biochemical and biophysical methods. Mechanisms of enzyme catalysis, gene expression, membrane structure and function, metabolic regulation, physical biochemistry, molecular genetics, cell biology, neurobiology, and related topics. Topics posted in advance. Required every semester in residence.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 15 hours.
605 Journal Club in Neurophysiology/Physiology (1) Readings and discussion based on current literature.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 12 hours.
606 Journal Club in Structural Biology/Biochemistry (1) Readings and discussion based on current literature.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 12 hours.
607 Journal Club in Cellular/Molecular Biology (1) Readings and discussion based on current literature.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 12 hours.
608 Journal Club in Genetics/Developmental Biology (1) Readings and discussion based on current literature.
Grading Restriction: Satisfactory/No Credit grading only.
Repeatability: May be repeated. Maximum 12 hours.
610 Current Topics in Biochemistry, Cellular, and Molecular Biology (1-3) Critical reviews of research problems and methods in biochemistry, cell biology and/or molecular biology. Oral presentations, written reports, computer simulations by faculty and students.
Repeatability: May be repeated. Maximum 4 hours.
Registration Permission: Consent of instructor.
612 Advanced Topics in Environmental Toxicology (1-3) (See Ecology and Evolutionary Biology 612.)
615 Special Topics in Biochemistry, Cellular, and Molecular Biology (3) Biochemical and biophysical methods, mechanisms of enzyme catalysis, gene expression, membrane structure and function, metabolic regulation, physical biochemistry, molecular genetics, cell ultrastructure and physiology, neurobiology, and related topics.
Repeatability: May be repeated. Maximum 9 hours.
(DE) Prerequisite(s): 511 and 512 or consent of instructor.